Compared with 18 46, XY inmates, 9 47, XYY inmates (1) incurred their first conviction at a younger age (mean age 13.1 years for 47, XYY; 18 years for 46, XY, (2) less often had a sibling who had received a conviction (1/31 siblings of 47, XYY inmates; 13/63 sibs of 46, XY inmates), and (3) committed crimes against property more often than crimes against persons.
As in all cases of prenatal diagnosis, the couple must make the ultimate decision of whether to continue the pregnancy.
Their decision must be supported by the physician and the entire genetic counseling team.
Henry and Emma Meyer Chair in Obstetrics and Gynecology, Professor, Obstetrics and Gynecology, Professor, Molecular and Human Genetics, Director, Division of Reproductive Medicine, Baylor College of Medicine, Houston, Texas Professor of Obstetrics and Gynecology and Molecular Genetics; Director, Division of Reproductive Genetics, Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois Both polysomy Y in males (47, XYY; 48, XYYY; 48, XXYY; 49, XXYYY) and polysomy X in females (47, XXX; 48, XXXX; 49, XXXXX) may be encountered by obstetricians-gynecologists as (1) an abnormal fetal chromosome complement detected by chorionic villus sampling, amniocentesis, or percutaneous umbilical blood sampling or (2) part of an evaluation for infertility, abnormal sexual development, other congenital malformations, or mental aberrations.
Polysomic sex chromosome complements may also provide valuable information concerning sex chromosome function and abnormalities of meiosis or mitosis.
The occurrence of double aneuploidy, for example, 48, XYY, 21, raises the possibility that genetic factors could be important in the etiology of polysomy Y.
who studied inmates at a Scottish maximum security prison.
For several years thereafter, relatively few cases were reported, but in 1965-1966, several investigators reported that among mentally retarded criminals the prevalence of 47, XYY was higher than expected by chance, creating a resurgence of interest in this disorder.
Among a total of 13,406 male infants studies, 9 (0.07%) were determined to have two Y-bodies.
The most likely origin of 47, XYY is paternal nondisjunction at meiosis II, resulting in 24, YY spermatozoa, followed by syngamy with a normal 23, X ovum.