His character died in the episode, but Ackles returned to the show as a series regular in the second season as Ben's sane clone, Alec/X5-494.
He remained with the show until its cancellation in 2002. He joined the cast of the WB's hit show Dawson's Creek during its final season, playing CJ, Jen Lindley's lover.
In 2005, Ackles joined the cast of the WB show horror/drama series Supernatural where he stars as Dean Winchester.
Dean and his brother Sam (Jared Padalecki) drive throughout the United States hunting paranormal predators, fighting demons and angels, and dealing with all manner of fantasy & sci-fi genre.
He also auditioned for the role of the young Clark Kent on Smallville, a role offered to actor Tom Welling instead.
Next he appeared in a guest role on the James Cameron television series Dark Angel on Fox in 2001 as serial killer Ben/X5-493, the brother of main character Max/X5-452 (played by Jessica Alba).
Ackles currently stars as Dean Winchester on the CW series Supernatural. Ackles had planned to study sports medicine at Texas Tech University and to become a physical therapist, but instead moved to Los Angeles to start his acting career.
After modelling on and off since the age of 4, Ackles began to concentrate on an acting career in 1996. Rhodes, Sweet Valley High, and Cybill before joining the cast of the NBC soap opera Days of Our Lives as Eric Brady in 1997.
Afterward, Ackles filmed several episodes of the unaired series Still Life for Fox before it was abruptly dropped.
Ackles turned down the role, which was then offered to Eric Christian Olsen and the character's name was changed to "Jensen" because the producers of Tru Calling liked Ackles' name.
Some people say he is now dating Jared Padaleckie because they do share a house and he is know single.
If you are going to make a smart remark, at least spell his name correctly, it's Jared Padalecki.
The show is currently in its twelfth season on the CW.